In glioblastoma, inhibition of miR-21 leads to upregulation of the matrix metalloproteinase inhibitors, a reversion inducing cysteine-rich protein with Kazal motifs (RECK), and TIMP metallopeptidase inhibitor 3 (TIMP3), which decreases glioma motility and activates caspases [83]. The gene discussed is TIMP3; the disease is central nervous system cancer.