For example, the Gp100 antigen and the mutated triosephosphate isomerase antigen-derived peptides were recognized by specific CD4+ T cells in the context of MHC-II HLA-DR and the cancer testis NY-ESO-1 antigen in the context of HLA-DP4 on melanoma cell lines [7,45,46]. This evidence concerns the gene CD4 and melanoma.