The fusion genes MAN2A1-FER found in hepatocellular carcinoma (HCC) and TMEM135-CCDC67 in prostate cancer (PC) offer the means of designing CRISPR/Cas9 therapies for the insertion of suicidal genes, such as the one for thymidine kinase (TK), that catalyzes the conversion of the harmless Ganciclovir to cell toxic compound, therefore mediating tumor cell death [94]. Here, TMEM135 is linked to hepatocellular carcinoma.