The tumor suppressor gene TP53, which is also called the “guardian of the genome”, is a key player in cell homeostasis, being involved in DNA damage response and apoptosis; and it is no surprise that almost half of the human malignant tumors harbor a mutated form of TP53, that reflects in the malignant phenotype of cancer cells, and often it is associated with a very poor prognosis [32]. The gene discussed is TP53; the disease is cancer.