As shown in Figure 2, ratios of the three AAbs, in particular IGFBP5-AAb and HAPLN1-AAb, noticeably declined at 3 and 12 months after tumor resection (Figure 2B,C, respectively), albeit the reduction in the ratio of TYMS-AAb was not statistically significant (Figure 2A). The gene discussed is HAPLN1; the disease is neoplasm.