The only study that demonstrated a possible prognostic role of hot-phase episodes is that of Wang et al. [15], which identified 91 individuals (34% male, median age 27.5) carrying a pathogenic or likely pathogenic DSP variant, and found that proband status and myocardial injury were prognostic for HF in univariate analysis, while in multivariate analysis these two variables did not reach statistical significance. This evidence concerns the gene DSP and hydrops fetalis.