PHLPP1 and colorectal carcinoma: In CRC, CircIL4R acts as a sponge for miR-761, while the E3 ligase TRIM29 is a downstream target of miR-761, and circIL4R activates the PI3K/AKT signaling pathway through the TRIM29-mediated ubiquitination and degradation of PHLPP1, thereby promoting CRC cell proliferation and transfer in vivo [84].