In the study of Xie et al., the authors found that circSHKBP1 regulates gastric cancer(GC) cell proliferation, migration and invasion in vivo and in vitro [80], and mechanistically, overexpression of circSHKBP1 reduced the amount of STUB1 binding to HSP90 by IP detection, verifying that circSHKBP1 and STUB1 are similar in the site competes with HSP90 for binding, leading to the conclusion that circSHKBP1 directly binds to HSP90 and inhibits the ubiquitination of HSP90 by STUB1, thereby accelerating GC development. This evidence concerns the gene STUB1 and gastric cancer.