FGF2 and Mental deterioration: In aging-induced cognitive decline, Rg1 incited apoptosis in the hippocampus and prefrontal cortex by promoting the expression of anti-apoptotic protein Bcl-2 and enzyme cleaved-caspase3; moreover, the expression decline of fibroblast growth factor 2 (FGF2) and BDNF can be restored by Rg1 treatment [125].