For example, the blockade of FKBP51 in a bronchial epithelial cell line resulted in a tenfold increase in the effectiveness of dexamethasone in suppressing IL-6 and IL-8, while the overexpression of FKBP51, on the contrary, reduced sensitivity to prednisolone in a model of pneumonia in mice [104]. The gene discussed is FKBP4; the disease is susceptibility to pneumonia measurement.