In cancers, NF-κB is considered an oncogene involved in tumorigenesis, cancer cell proliferation, and resistance to apoptosis and is a key player in the cancer microenvironment cells as well as their crosstalk with the cancerous cells [85], particularly in CRC, where NF-κB is being considered as a potential biomarker [86]. The gene discussed is NFKB1; the disease is colorectal carcinoma.