CPSF4 and central nervous system cancer: Indeed, we have previously shown that NAR, as well as LYC, exerts marked anti-migratory effects in glioma and melanoma cells depending on Rho A/ Rho-associated kinase (ROCK) and/or eukaryotic elongation factor 1 alpha (eEF1α)-mediated regulation of actin cytoskeleton polymerization and bundling [66,67,68].