CCL4 and colorectal carcinoma: Based on the recent review by Gunawardene et al. [50], we examined the effects of Amaryllidaceae alkaloids on cytokine levels found to be predictors of overall or disease-free survival for CRC patients; specifically IL-2, IL-6, IL-8, CCL-4, CCL-22, Flt-3 ligand, IFNγ, VEGF, and pentraxin 3.