Using a recombinant CD38 protein, van de Donk et al. showed that the anti-CD38 monoclonal antibody Dara can reverse the tumor-promoting activities of the CD38 ectoenzyme by reducing ADPR cyclase activity and inducing cADPR hydrolase activity, thus increasing NAD+ and ADPR levels and decreasing cADPR levels [43]. The gene discussed is CD38; the disease is neoplasm.