A number of Fn-docking molecules on target cells have been identified, including the colon-cancer-associated carbohydrate moiety Gal-GalNac (via bacterial Fap-2) [9], E-cadherin (through the Fn adhesin FadA) [8], and the carcinoembryonic antigen-related cell adhesion molecule family member 1 (CEACAM-1), via the trimeric autotransporter adhesin CbpF [11]. Here, FN1 is linked to malignant colon neoplasm.