RNPC3 and neoplasm: Yin et al. developed an ultrasound-controlled CRISPR/Cas9 release system, in which the hematoporphyrin monomethyl ether (HMME) yielded abundant ROS to damage tumor cells under ultrasound irradiation, and meanwhile the generated ROS could induce lysosomal rupture to release RNP and destroy the oxidative stress-defense system, ultimately significantly promoting tumor cell apoptosis [80].