HIF1A and neoplasm: Li et al. designed cationic liposomes modified with R8-DGR, whose fluorescence at different depths was significantly higher than other liposomes in the 3D tumor spheroid model, showing good tumor deep penetration ability and contributing to tumor eradication by targeted delivery of CRISPR/Cas9 system to knockdown of hypoxia-inducible factor-1 alpha [73].