One example of this is that circNDUFB2 can function as a scaffold to enhance the binding between TRIM25 and IGF2BPs and then facilitate the ubiquitination level of IGF2BPs, participating in the activation of anti-tumor immunity via RIG-I-MAVS signaling cascades during non-small cell lung cancer (NSCLC) progression [83]. The gene discussed is TRIM25; the disease is non-small cell lung carcinoma.