AKT1 and renal cell carcinoma: This function is also presented in different diseases; ciRS-7 was observed to strongly suppress miR-7 activity in neuronal tissues [68], however, it could also act as a sponge of miR-139-3p in renal cell carcinoma (RCC) to target TAGLN, which activated the PI3K/AKT signaling pathway and promoted cell proliferation, migration and invasion [72].