CGAS and heart failure: A study made by Lei, Y. et al., in 2022, stated that ZBP1 can be considered a new regulator of IFN-1-mediated disease progression, acting on the cGAS-STING pathway to sense mitochondrial DNA (mtDNA) instability and sustain IFN-1 signaling, which has a role in heart failure and cardiac cell remodeling [15].