Therefore, targeting both branches of the oxidant/antioxidant ratio through various pathways, such as the Nuclear factor erythroid 2-related factor 2/Kelch-like ECH-associated protein 1/Antioxidant responsive element (NRF2/KEAP1/ARE) pathway, can prove to be an efficient approach in the prophylaxis and management of DKD [15]. Here, NFE2L2 is linked to diabetic kidney disease.