HAS1 and cancer: In addition, dysregulation of WTAP affected the expression of many hub genes involved in cancer cell migration, such as matrix metallopeptidase 3 (MMP3), thrombospondin 1 (THBS1), C-C motif chemokine ligand 2 (CCL2), C-C motif chemokine ligand 3 (CCL3), lysyl oxidase like 1 (LOXL1), and hyaluronan synthase 1 (HAS1) [137].