Previous work from our lab demonstrated that, in a mouse model based on stereotaxic delivery in the hippocampus of an adeno-associated viral vector for expression of TAUP301L, a mutated form of TAU associated with FTD, NRF2 signaling pathway was increased in astrocytes and microglia and treatment with the NRF2 inducer DMF provided neuroprotection [21,23]. The gene discussed is NFE2L2; the disease is frontotemporal dementia.