CASP1 and psoriasis: However, after brief MS in early life, mice with psoriasis-like skin lesions showed decreased activation of microglia and decreased expression of the NLRP3/Caspase-1/IL-1β pathway in the hippocampus, which suggests that even though brief MS did not inhibit the activation of skin inflammation, brief MS may have prevented depressive-like behaviors by inhibiting microglial activation in adulthood.