A multimodal study with dopamine transporter (DAT) SPECT and FDG PET demonstrated that a degeneration of the cognitive striatum, as measured by [123I]FP-CIT binding ratios, is related to a reduced glucose metabolism in the anterior cingulate [175], which emphasizes the link between PD progression and the development of cognitive deficits. The gene discussed is SLC6A3; the disease is Cognitive impairment.