Obesity was shown to increase the expression of many proinflammatory markers, including CRP [114], plasminogen activator-1 inhibitor [115], IL-6 and TNFα [116], monocyte chemokine CCL2, or MCP-1 [117], and acute phase protein—serum amyloid [118]. The gene discussed is CCL2; the disease is obesity due to melanocortin 4 receptor deficiency.