CSF TMAO: higher in AD dementia and MCI vs. controls after controlling for age, sex, and APOE ε4 genotype; positively associated with age; did not differ between MCI and ADCSF biomarkers: CSF TMAO positively related to p-tau, p-tau/Aβ42, t-tau, and NFL, not related to Aβ42/Aβ40 nor neurogranin, associations did not change when including peripheral cardiovascular disease risk factors as covariates. Here, NRGN is linked to cardiovascular disorder.