Lei et al. [18] did not find differential expressions of histidine decarboxylase (HDC), HECT domain and RCC-1 like domain 1 (HERC1), HECT domain and RCC-1 like domain 2 (HERC2), cholinergic receptor, neuronal nicotinic alpha polypeptide 7 (CHRNA7), ubiquitin protein ligase E3A (UBE3A), or ubiquitin specific peptidase 3 (USP3) in TS subjects (n = 30) compared with NC subjects (n = 30). This evidence concerns the gene UBE3A and Timothy syndrome.