JAK2 and epilepsy: Differential gene-expression analysis further identified 21 genes with statistical significance, consisting of 18 up-regulated genes (ACSL4, ADIPOR1, ADIPOR2, AKT1, CAMKK2, CPT1A, CPT1B, JAK2, NFKB1, NFKBIE, PCK2, PRKAB1, PRKAG1, RELA, RXRA, STAT3, TNFRSF1A, and TNFRSF1B) and 3 down-regulated genes (LEP, PRKAB2, and PRKCQ) in epilepsy cases (Figure 2b,c).