The expression levels of ACSL4, ADIPOR1, CAMKK2, CPT1A, CPT1B, JAK2, NFKBIE, RELA, STAT3, TNFRSF1A, and TNFRSF1B in cluster B were higher than that in cluster A, while the levels of PRKAB2 and PRKCQ were significantly decreased in cluster B, revealing the diversity of adipocytokine signaling expression patterns in epilepsy. The gene discussed is NFKBIE; the disease is epilepsy.