Through machine learning algorithms, five adipocytokine pathway-related genes (RELA, PRKAB1, TNFRSF1A, CAMKK2, and CPT1B) robustly correlated with epilepsy were screened out as molecular biomarkers for disease prediction and could assist neurologists in making more accurate diagnoses, not only using the patient’s symptoms, MR imaging, EEG, etc. RELA, as a member of the NF-κB/Rel family of transcription factors, participates in diverse cellular responses like immunity, inflammation, tumorigenesis, apoptosis, and differentiation in the form of homodimers or heterodimers [24]. This evidence concerns the gene RELA and epilepsy.