Based on the published articles, we speculate that both a ZiBuPiYin recipe [53], which was recorded in the book of Bujuji written by Cheng Wu in the Qing dynasty, and Luks-PV [54] which is a pore-forming leukocidin secreted by Staphylococcus aureus, have potential roles in the prevention and treatment of depression because of their reductions in the levels of the NUCB1 protein. Here, NUCB1 is linked to depressive disorder.