The ACS and AD expressed higher serum levels of ABCA1, ABCG1, LXRβ and SREBP1 but lower serum levels of ApoD, ApoE, ApoH, c_Myc, COX2, LXRα, MST1, MST2, Nanog, PPARγ, TAZ and YAP. The gene discussed is APOE; the disease is Alzheimer disease.