Neurons in the brains of AD patients and AD mice show reduction of sphingosine kinase1 (SphK1), leading to defective microglial phagocytosis, decreased secretion of specialized proresolving mediators (SPMs) and reduction of acetyl-CoA-dependent cytoplasmic acetyltransferase activity towards COX2 [36]. The gene discussed is PTGS2; the disease is Alzheimer disease.