TPM4 and central nervous system cancer: Unique to our analysis, through an integrative study of the molecular characteristics, prognostic value, as well as the biological function of TPM4 expression deriving from TCGA and CGGA datasets, we highlight that TPM4 is another critical predictor of poor prognosis and might correlate with malignant biological behaviors during gliomagenesis, which would further deepen our understanding of the potential role of the TPM family in glioma.