Tropomyosin 4 (TPM4), a member of the tropomyosin family, has been widely reported across different malignancies, including oral squamous cell carcinoma (OSCC) [3], breast cancer [4,5], lung cancer [6,7], hepatocellular carcinoma (HCC) [8], ovarian cancer [9], uterine cervix cancer [10], and colon cancer [11]. Here, TPM4 is linked to oral cavity squamous cell carcinoma.