The increase in body fat during obesity is directly associated with the appearance of numerous metabolic and physiological processes, such as the modification in fiber type from slow to fast, a decrease in the number of fibers and their diameter; an accumulation of fat between the fibers, trigger insulin resistance, and establish a state of chronic inflammation [1,6,7], eventually affecting normal contractile function [8] and favoring the development of fatigue [9]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.