The human p53 protein contains 393 amino acids and has been divided structurally and functionally into five domains with specific hot spots for mutations in human cancer: (1) an acidic amino-terminal domain (aa ~1–61), which is required for transcriptional activation, (2) a proline-rich domain (aa ~64–92), (3) a central core sequence-specific DNA-binding domain (aa ~100–300), (4) a tetramerization domain (aa ~323–355) and (5) a C-terminal regulatory domain (aa ~364–393) [21]. This evidence concerns the gene TP53 and cancer.