CXCL8 and infection: ↑ 1384 genes, ↓1542 genes↑ pro-inflammatory cytokines and signal-transduction-related genes (il1β, il8, tnfα, TNF receptors, CXC chemokines, tgfβ)Antibacterial mechanism at early-stage infection (24 hpi) involved cytokine–cytokine receptor interactionsImmune pathway: JAK-STAT signaling