GALT and classic galactosemia: Current approaches for the treatment of galactosemia include neonatal screening [146] followed by dietary management via the reduction or substitution of galactose and lactose; however, long-term therapy required additional interventions such as molecular chaperones to correct the misfolded [147] GALT enzyme [148] and the reliance on animal models to characterize the genetic association between GALT mutations and galactosemia [149].