IL6 and posterior cortical atrophy: Bone marrow reactive stromal cells produce factors including interleukin 6 (IL-6), transforming growth factor beta (TGFβ), and tumor necrosis factor alpha (TNF-α) that induce apoptosis and neuroendocrine differentiation in PCa cells [3,4] and activate the transcription of matrix proteins such as perlecan [5] and tenascin-C [6] in the reactive stroma.