IGF1 and hyperinsulinemic hypoglycemia, familial, 4: On gestational day 19, the weight gain of the pregnant dams during gestation was compared between all groups, and it was found that both HZ groups (HZ-Control, 16.78 g ± 0.92; and HZ-Ethanol, 17.37 g ± 0.96) weighed less than the WT groups (WT-Control, 23.94 g ± 1.01; and WT-Ethanol, 24.67 g ± 2.41; p < 0.001), and this effect was not altered by the ethanol treatment (Figure 2A), suggesting that partial IGF-1 deficiency is responsible for the lower weight gain in pregnant females throughout pregnancy.