Ethanol consumption during gestation diminishes body weight and food consumption during this period, increases placental weight and Cyp2e1 expression in the livers of HZ pregnant dams, and blights the antioxidant system, suggesting impairments in placental development, which could lead to an altered nutrient exchange, resulting in malnutrition and poor fetal development. Here, CYP2E1 is linked to nutritional deficiency disease.