IGF1 and hyperinsulinemic hypoglycemia, familial, 4: In this sense, as seen before in reports from our research group, the mouse model used in the present study authentically represents the pathophysiological conditions associated with partial IGF1 deficiency, such as alterations of the hepatic architecture, mitochondrial damage, and lower body weight, among others, thus being a vital implement for the study of the pathological alterations associated with partial IGF-1 deficiency.