IP6K1 and obesity due to melanocortin 4 receptor deficiency: To assess impacts of IP6K1 inhibition on obesity-induced bone loss, we subjected 2-month-old mice to HFD feeding for 100 d under thermo-neutral conditions to prevent adaptive thermogenesis and after 40 d administered daily injections of vehicle or TNP (10 mg/kg BW) [37] (Figure 1a).