The most recognized entities are EEC syndrome (ectodermal dysplasia, ectrodactyly and cleft lip/palate syndrome; MIM#129900), Hay–Wells or AEC syndrome (ankyloblepharon, ectodermal dysplasia and cleft lip/palate syndrome; MIM#106260) and Rapp-Hodgkin syndrome (MIM#129400), all of which are caused by heterozygous mutations in the TP63 gene. Here, TP63 is linked to ectodermal dysplasia syndrome.