TNF and sleep apnea syndrome: In contrast to the initial hypothesis, that children do not exhibit daytime sleepiness like adults with SDB [42], and rather show hyperactive behavior during the day, some recent studies have been able to recognize and document the presence of objective daytime sleepiness in children with SDB, particularly in obese children and children with specific polymorphisms in the gene encoding for tumor necrosis factor α [43,44,45,46,47].