Importantly, the differential expression of UBE2S and UBE2C across histologic subtypes were further corroborated in bulk transcriptome from the TCGA and the East Asian ancestry (EAS) cohorts, as well as proteome from the Clinical Proteomic Tumor Analysis Consortium (CPTAC) cohort (Fig. 1D, Additional file 8: Fig. S2C–D; Methods). Here, UBE2S is linked to neoplasm.