Saremi et al. [47] evaluated the influence of immune gene polymorphisms on the development of peri-implantitis and revealed that allele and genotype frequencies of IL-10 ─ 819 C/T, IL-10 ─ 592 C/A, and IL-1ß + 3954 C/T, significantly differed between diseased and healthy patients, indicating that these specific gene polymorphisms may play a role in the pathogenesis of peri-implantitis. This evidence concerns the gene IL1B and Peri-Implantitis.