LEP and type 1 diabetes mellitus: Few studies have evaluated the impact of maternal T1DM on offspring epigenetic changes, and included studies exploring an adult cohort including both offspring born to women with gestational diabetes and T1DM, using muscle, adipose tissue, or preadipocytes, described increased expression of microRNA-15a and microRNA-15b in skeletal muscle tissue and decreased leptin promotor methylation in subcutaneous adipocytes in offspring of T1DM women [12, 14–17].