In the sensitivity analyses, after excluding 26 participants who developed CRC within the 1st year of follow-up, 911 individuals who took statins at baseline, 2365 participants who received oral hypoglycemic agents or insulin, 1881 or 1893 participants with extreme values of TyG index or TG/HDL-C ratio, significant associations of the TyG index and TG/HDL-C ratio with the risk of CRC incidence were still observed (Table 4). The gene discussed is INS; the disease is colorectal carcinoma.