PACS2 and injury: As we all know, the triglycerides themselves serve primarily a storage function with toxicity deriving mainly from FFA, FC, CE, ceramides, etc. (Listenberger et al. 2003; Nakamichi et al. 2021; Tang et al. 2010), indicating PACS-2 may have a renoprotective role from lipid-related kidney injury in DKD.