These data underscore the contributions of adegramotide to the effector function of nelatimotide-induced cytotoxic T cells, supporting the inclusion of both WT1-specific CD8+ and CD4+ epitopes; demonstrate how the IFN-γ–secreting ability of DSP-7888 Emulsion-induced CD8+ T cells is generally preserved in the presence of tumor cells; and illustrate the potential synergy between DSP-7888 Emulsion and immune checkpoint inhibition. The gene discussed is CD4; the disease is neoplasm.