VEGFA and neoplasm: Hodgkin lymphoma-derived exosomes can facilitate the transformation of normal fibroblasts into tumor-specific fibroblasts, which causes the release of proinflammatory cytokines (e.g., IL-1α, IL-6, and TNF-α), growth factors (e.g., G-CSF and GM-CSF) and proangiogenic factors (e.g., VEGF)28,69.