RAC1 and inflammatory bowel disease: Rac1-corrected pSTAT3 protein levels in IBD patients groups on thiopurine monotherapy AZA/MP (median 0.66 AU) or TG (median 0.68 AU) were reduced compared to IBD patients with active disease with borderline significance (median 1.33 AU) (p = 0.018 and p = 0.016, respectively) (Fig. 4C).