We found that the expression of IFN genes, either IFNα or IFNλ1, was significantly reduced upon mtp53 depletion in breast cancer cell lines BT-549, MDAMB-468, MDAMB-231, a bladder cancer cell line J82 and mouse fibrosarcoma MCO4 (Fig. 2a). The gene discussed is IFNL1; the disease is breast carcinoma.