Mtp53-reactivating compound APR-246 (commercial name eprenetapopt), identified by us [12], has been shown to suppress tumours not only via restoration of p53 tumour suppressor function, but also by other mechanisms, including induction of oxidative stress, endoplasmic reticulum (ER) stress and ferroptosis [13, 14]. Here, TP53 is linked to neoplasm.