IFNB1 and breast carcinoma: As shown in Fig. 5b, APR-246 treatment induced type I IFN (IFNα & IFNβ), type III IFN (IFNλ2/3) and some downstream interferon sensitive genes (ISGs) in human colorectal cancer cell line DLD-1 and human breast cancer lines BT-20 and BT-549.