Of note, APR-246-mediated upregulation of IFNα and the downstream target STAT2 was mtp53-dependent, as well as the induction of p53 target genes p21 (CDKN1A) and Noxa (PMAIP1) as shown in the DLD-1 cancer cell line (Fig. S4c). The gene discussed is STAT2; the disease is cancer.