TNF and breast carcinoma: These include cytokines which facilitate the infiltration of CD8+ T cells, CCL2, CCL3, CCL4, CCL5, CXCL9 and CXCL10; cytokines engaged in the growth and proliferation of CD8+ T cells, IL-7, IL-12 and IL-15; cytokines involved in the priming and activity of CD8+ T cells, IL-17 and TNF-α, and IFN-γ, respectively, while TGF-β, the inhibitory cytokine of CD8+ T cells was decreased in mtp53 breast cancers (Fig. 3b).