SETD2 (Group 2: prevalence = 3.5%, χ2 = 11.7, P value = 4.2 × 10−3, Group 3: prevalence = 22.2%, χ2 = 42.6, P value = 6.6 × 10−10) and PBRM1 (Group 2: prevalence = 0.9%, χ2 = 15.9, P value = 5.0 × 10−4, Group 3: prevalence = 16.5%, χ2 = 40.9, P value = 1.5 × 10−9) were significantly different compared to the entire pleural mesothelioma cohort (Fig. 2 and Table 1). Here, PBRM1 is linked to pleural mesothelioma.