The five most frequently altered genes in pleural mesothelioma were CDKN2A (48.2%), BAP1 (45.0%), CDKN2B (42.2%), NF2 (32.8%) and MTAP (32.3%), in peritoneal mesothelioma BAP1 (47.9%), NF2 (26.5%), CDKN2A (25.9%), CDKN2B (19.5%), PBRM1 (15.8%) (Fig. 1 and Supplementary Tables 1–3). The gene discussed is NF2; the disease is pleural mesothelioma.