Mechanistically, we find that FAK-dependent secretion of interleukin-6 (IL6) from LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre murine pancreatic cancer cells can amplify interleukin-4 (IL4) induced expression of PD-L2, but that IL6 alone cannot promote expression of PD-L2. Here, IL6 is linked to familial pancreatic carcinoma.