During acute mucosal Candida infection, epithelial EphA2 activates distinct chemokines, cytokines, and host defense peptides to prevent fungal invasion39,45,46, while EphA2 in neutrophils is required for p47phox priming to enhance fungal clearance40; thus, EphA2 in hematopoietic and nonhematopoietic cells contributes to resistance against oral infection. The gene discussed is EPHA2; the disease is candidiasis.