Further analysis of RCC patient specimens using a protein array showed that higher levels of phosphorylated kinases, such as Src and Yes, FAK, Pyk2, β-catenin, and STAT3, were related to tumor invasiveness and metastasis, as these factors were upregulated in grade III and IV specimens versus grade I and II specimens (Fig. 8E). This evidence concerns the gene YES1 and renal cell carcinoma.