In addition, we observed the activation of proteins involved in the rearrangement of the cytoskeleton, such as RhoB and fibronectin, as well as Yes1, a Src family tyrosine kinase, after treatment of HUVECs with CM from sunitinib- or sorafenib-resistant ccRCC cells (Fig. 5D). The gene discussed is YES1; the disease is nonpapillary renal cell carcinoma.