Nevertheless, m6A can influence the anti-tumor response of CD8+ T cells via controlling the biological processes of other related cells in the TIME, such as tumor cells, macrophages, and DCs.346,347,423 Especially, the progression of multiple myeloma, a B-cell lymphoma, is mediated by m6A in an FTO and YTHDF2 dependent manner.357 Relatively, there are no comprehensive studies on the biological functions and molecular mechanisms of other modifications regulating immune cells in cancers till now. This evidence concerns the gene CD8A and cancer.