FTO and malignant colon neoplasm: For example, Ythdf1-deficient mice exhibited an elevated antigen-specific CD8+ T cell antitumor response.346 In tumor-associated macrophages, METTL14 deficiency led to anomalous CD8+ T cell differentiation, driving CD8+ T cell dysfunction and repressing CD8+ T effector cell activation.347 Tumor-intrinsic FTO restricted the activation and effector states of CD8+ T cells; knockdown of FTO impaired tumor cell glycolytic activity, which restored CD8+ T cell function.347 m1A levels were negatively related to CD8+ T effector cell proliferation in colon cancer.348