In addition to promoting tumor proliferation, migration, and invasion, it has also been found to have related effects in promoting tumor cell resistance to radiotherapy and chemotherapy and immune escape.25,26 Our results indicated that PSMD12 can promote the malignant biological phenotype of HCC cells, and this function is achieved by activating the MEK-ERK pathway. The gene discussed is PSMD12; the disease is hepatocellular carcinoma.